Safety Difficult to Treat

ILUMYA® demonstrated consistent safety outcomes in patients with scalp psoriasis, patients age 65 and older, and patients with metabolic syndrome1-4

For patients with moderate-to-severe scalp psoriasis1*:

PROVEN SCALP RESPONSE

ILUMYA® provided a significant reduction in moderate-to-severe scalp psoriasis compared with placebo1

SEE RESULTS

For patients ≥65 years of age in reSURFACE 1 and 2:

AFFORDABLE TREATMENT FOR OLDER PATIENTS

Medical benefit coverage may help reduce out-of-pocket costs
to as low as $0 for patients with Medicare Part B

EXPLORE SUPPORT PROGRAMS AND SERVICES

For patients with moderate-to-severe plaque psoriasis and metabolic syndrome in reSURFACE 1 and 2:

INDICATION AND IMPORTANT SAFETY INFORMATION

ILUMYA® (tildrakizumab-asmn) is indicated for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

CONTRAINDICATIONS

ILUMYA is contraindicated in patients with a previous serious hypersensitivity reaction to tildrakizumab or to any of the excipients.

WARNINGS AND PRECAUTIONS

Hypersensitivity

Cases of angioedema and urticaria occurred in ILUMYA-treated subjects in clinical trials. If a serious allergic reaction occurs, discontinue ILUMYA immediately and initiate appropriate therapy.

Infections

ILUMYA may increase the risk of infection. Treatment with ILUMYA should not be initiated in patients with a clinically important active infection until the infection resolves or is adequately treated.
Consider the risks and benefits of treatment prior to prescribing ILUMYA in patients with a chronic infection or a history of recurrent infection. Instruct patients receiving ILUMYA to seek medical help if signs or symptoms of clinically important chronic or acute infection occur. If a patient develops a clinically important or serious infection, or is not responding to standard therapy, closely monitor and consider discontinuation of ILUMYA until the infection resolves.

Pretreatment Evaluation for Tuberculosis

Evaluate patients for tuberculosis (TB) infection prior to initiating treatment with ILUMYA. Do not administer ILUMYA to patients with active TB infection. Initiate treatment of latent TB prior to administering ILUMYA. Consider anti-TB therapy prior to initiation of ILUMYA in patients with a past history of latent or active TB in whom an adequate course of treatment cannot be confirmed. Patients receiving ILUMYA should be monitored closely for signs and symptoms of active TB during and after treatment.

Immunizations

Prior to initiating therapy with ILUMYA, consider completion of all age-appropriate immunizations according to current immunization guidelines. Patients treated with ILUMYA should not receive live vaccines.

Adverse Reactions

The most common (≥1%) adverse reactions associated with ILUMYA treatment that were more frequent than in the placebo group are upper respiratory infections, injection-site reactions, and diarrhea.

Please see full Prescribing Information.
 

References: 1. Data on File. Sun Pharmaceutical Industries, Inc. 2. Van der Kerkhof P, Daudén E, Schoenenberger A, Ryzhkova A, Pau-Charles I. Long-term safety of tildrakizumab in patients 65 years of age or older with moderate-to-severe psoriasis: pooled analysis through 5 years from reSURFACE 1 and reSURFACE 2 phase 3 trials. Poster presented at: 29th Congress of the European Academy of Dermatology and Venereology (EADV); October 29-31, 2020; Barcelona, Spain. 3. Wei NW, Chi S, Lebwohl MG. Retrospective analysis in patients with moderate to severe plaque psoriasis treated with tildrakizumab: real-life clinical data. J Psoriasis Psoriatic Arthritis. 2022;7(2):55-59. 4. Lebwohl MG, Leonardi CL, Mehta NN, et al. Tildrakizumab efficacy, drug survival, and safety are comparable in patients with psoriasis with and without metabolic syndrome: long-term results from 2 phase 3 randomized controlled studies (reSURFACE 1 and reSURFACE 2). J Am Acad Dermatol. 2021;84(2):398-407.